St. Lucie County Commercial Real Estate
456 commercial properties for sale and lease in St. Lucie County right now, asking $25K to $11M across the 200 priced sale listings. The newest was listed Oct 4, 2026; every asset-class page below carries its own live count.
Commercial real estate in St. Lucie County, by category
St. Lucie County is the Treasure Coast's growth engine. Port St. Lucie is one of Florida's fastest-growing cities, anchoring multifamily and retail demand. Industrial along I-95 north of PSL has emerged as a meaningful logistics corridor. Each page below carries its own live count.
Infill development opportunities in South Florida are increasingly scarce.
View inventory →Flex space is the office-warehouse hybrid: front showroom or office, rear roll-up door and warehouse, in units typically running 1,200 to 10,000 SF.
View inventory →South Florida hospitality benefits from year-round demand: leisure in winter, business and conferences in shoulder seasons, international flow at the major hubs.
View inventory →Industrial is South Florida's tightest asset class: under 3% vacancy in the strongest submarkets and rents up 8-12% year over year.
View inventory →Medical office is the strongest-performing office subtype in South Florida: an aging, growing population drives structural demand, buildout cost (exam-room plumbing, imaging shielding, generators) makes tenants sticky, and health-system affiliations bring credit to the rent roll.
View inventory →Mixed-use combines residential income with ground-floor retail or office, the highest-and-best-use solution for urban corridors.
View inventory →Multifamily remains South Florida's most resilient commercial asset class, driven by population growth, in-migration, and chronic single-family undersupply.
View inventory →Net-leased investments are the cleanest entry point for passive commercial real estate ownership: credit tenant, long lease, no landlord responsibilities.
View inventory →South Florida office defied the post-pandemic narrative.
View inventory →Restaurant real estate in South Florida is one of the tightest niches in commercial.
View inventory →South Florida retail has tightened significantly through 2025.
View inventory →Self-storage in South Florida has seen rapid institutional acquisition, but pockets of mom-and-pop ownership remain.
View inventory →Shopping centers are the rent-roll business of South Florida retail: strip, neighborhood, and community centers where the value lives in tenant mix, lease terms, and co-tenancy rather than any single storefront.
View inventory →Small-bay industrial is the scarcest slice of the tightest asset class in South Florida: multi-tenant buildings cut into 1,500 to 5,000 SF units serving contractors, installers, fabricators, and e-commerce operators.
View inventory →456 commercial properties in St. Lucie County

951 King Orange Drive

638 NW Grenada Street

6208 Emerson Avenue

6204 Emerson Avenue

642 Eldorado Street

646 Eldorado Street

642 & 646 Eldorado Street

1901 Orange Avenue

0 N Us 1 Highway

11099 Ridge Avenue

0 Old Dixie N Highway

3950 SW Port St Lucie Boulevard
Buying or selling commercial properties in St. Lucie County?
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Common questions about St. Lucie County commercial real estate
How many commercial properties are for sale in St. Lucie County right now?
456 for sale and lease as of Oct 4, 2026, across our own listings and the MLS feed. The count refreshes every five minutes.
What kinds of commercial real estate are for sale in St. Lucie County?
St. Lucie County Commercial Land for Sale; St. Lucie County Flex Space for Sale and Lease; St. Lucie County Hotels for Sale; St. Lucie County Industrial Properties for Sale; St. Lucie County Medical Offices for Sale and Lease; St. Lucie County Mixed-Use Properties for Sale and Lease; St. Lucie County Multifamily Properties for Sale; St. Lucie County NNN Properties for Sale; and 6 more. Each has its own page with a live count and current asking prices.
Do you have off-market commercial deals in St. Lucie County?
Yes. Sellers in St. Lucie County test pricing quietly against buyer mandates before listing. Post your criteria and we match new inventory against it as it surfaces, before it reaches a public platform.
Post your criteria →Other South Florida markets we work
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Whether you're buying, selling, leasing, or mid-1031, Atlantic Commercial Advisors works St. Lucie County every day.