Port St. Lucie Commercial Real Estate
161 commercial properties for sale and lease in Port St. Lucie right now, asking $25K to $11M across the 161 priced sale listings. The newest was listed Oct 4, 2026; every asset-class page below carries its own live count.
Commercial real estate in Port St. Lucie, by category
Port St. Lucie is one of Florida's fastest-growing cities: strong multifamily fundamentals, expanding retail demand along US-1 and Crosstown Parkway, and growing institutional interest in suburban retail and industrial. Each page below carries its own live count.
Infill development opportunities in South Florida are increasingly scarce.
View inventory →Flex space is the office-warehouse hybrid: front showroom or office, rear roll-up door and warehouse, in units typically running 1,200 to 10,000 SF.
View inventory →South Florida hospitality benefits from year-round demand: leisure in winter, business and conferences in shoulder seasons, international flow at the major hubs.
View inventory →Industrial is South Florida's tightest asset class: under 3% vacancy in the strongest submarkets and rents up 8-12% year over year.
View inventory →Medical office is the strongest-performing office subtype in South Florida: an aging, growing population drives structural demand, buildout cost (exam-room plumbing, imaging shielding, generators) makes tenants sticky, and health-system affiliations bring credit to the rent roll.
View inventory →Mixed-use combines residential income with ground-floor retail or office, the highest-and-best-use solution for urban corridors.
View inventory →Multifamily remains South Florida's most resilient commercial asset class, driven by population growth, in-migration, and chronic single-family undersupply.
View inventory →Net-leased investments are the cleanest entry point for passive commercial real estate ownership: credit tenant, long lease, no landlord responsibilities.
View inventory →South Florida office defied the post-pandemic narrative.
View inventory →Restaurant real estate in South Florida is one of the tightest niches in commercial.
View inventory →South Florida retail has tightened significantly through 2025.
View inventory →Self-storage in South Florida has seen rapid institutional acquisition, but pockets of mom-and-pop ownership remain.
View inventory →Shopping centers are the rent-roll business of South Florida retail: strip, neighborhood, and community centers where the value lives in tenant mix, lease terms, and co-tenancy rather than any single storefront.
View inventory →Small-bay industrial is the scarcest slice of the tightest asset class in South Florida: multi-tenant buildings cut into 1,500 to 5,000 SF units serving contractors, installers, fabricators, and e-commerce operators.
View inventory →161 commercial properties in Port St. Lucie

638 NW Grenada Street

3950 SW Port St Lucie Boulevard

5218 NW N Lovoy Circle

1038 SW Bayshore Boulevard

2449 Altara Street SW

2465 SW Altara Street

353 NW FOURSOME Lane

801 SW BILTMORE Street # 0

1762 SW Cochran Street

2134 And 2174 NW Commerce Lakes Drive NW

642 SE TANNER Avenue

1514 SE Port St Lucie Boulevard
Buying or selling commercial properties in Port St. Lucie?
Get new and off-market commercial properties in Port St. Lucie by email before they are widely marketed. One field, no spam, unsubscribe any time.
Asset class, submarket, price range, return target. We match your criteria against live listings and off-market owners, and send only what fits.
Post your criteriaA free broker opinion of value built on income, live asking data and recent comparable sales, not an automated estimate.
Common questions about Port St. Lucie commercial real estate
How many commercial properties are for sale in Port St. Lucie right now?
161 for sale and lease as of Oct 4, 2026, across our own listings and the MLS feed. The count refreshes every five minutes.
What kinds of commercial real estate are for sale in Port St. Lucie?
Port St. Lucie Commercial Land for Sale; Port St. Lucie Flex Space for Sale and Lease; Port St. Lucie Hotels for Sale; Port St. Lucie Industrial Properties for Sale; Port St. Lucie Medical Offices for Sale and Lease; Port St. Lucie Mixed-Use Properties for Sale and Lease; Port St. Lucie Multifamily Properties for Sale; Port St. Lucie NNN Properties for Sale; and 6 more. Each has its own page with a live count and current asking prices.
Do you have off-market commercial deals in Port St. Lucie?
Yes. Sellers in Port St. Lucie test pricing quietly against buyer mandates before listing. Post your criteria and we match new inventory against it as it surfaces, before it reaches a public platform.
Post your criteria →Let's talk.
Whether you're buying, selling, leasing, or mid-1031, Atlantic Commercial Advisors works Port St. Lucie every day.